Eco-friendly and facile production method, natural products chemistry, and pharmacological properties of silver nanoparticles using telfaria occidentalis leaf and stem extracts
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Daniel Ebubechi Obasi 1 , Ngozi Maryann Nebolisa 2 , Afuape Rapheal Akinwunmi 3 , Ayomide Khadijat Abimbolu 4 , Matthew Chukwudi Ezeorah 5 , Oluwafemi Michael Areola 6 , Uchechukwu Divine Donatus 7 , Victor Temitayo Oladipupo 8 , Jonah Joshua Ohiani 9 , Taiwo Aderonke Ayanleke 10 , Eniola Eunice Kolapo 11 , Surajudeen Adewumi Adeyemi 12 , Tosin Oluwashina Oseni 13 , Olumakinde Charles Omiyale 14 *
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1 Department of Medicine and Surgery, Faculty of Clinical Sciences, University of Ibadan, Ibadan, Oyo State, NIGERIA2 Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, NIGERIA3 Department of Biology, North Carolina Agriculture and Technical State University, Greensboro, NC, USA4 Department of Public Health, Middlesex University London, London, UK5 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Nsukka, Enugu State, NIGERIA6 Department of Industrial Chemistry, Federal University Oye-Ekiti, Oye-Ekiti, Ekiti State, NIGERIA7 Department of Chemical Engineering, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State, NIGERIA8 Department of Electrical and Electrical Electronics Engineering, The Federal University of Technology, Akure, Ondo State, NIGERIA9 Department of Pharmaceutical Chemistry, University of Jos, Jos, Plateau State, NIGERIA10 Department of Applied Chemistry, Osun State Polytechnic, Iree, Osun State, NIGERIA11 Department of Pharmaceutical Chemistry, University of Ibadan, Ibadan, Oyo State, NIGERIA12 Department of Industrial Chemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Osun State, NIGERIA13 University of Lagos, Akoka. Lagos State. NIGERIA14 Department of Pharmacology, Toxicology and Therapeutics, College of Medicine, University of Lagos, Lagos, Lagos State, NIGERIA* Corresponding Author

Abstract

Using an extract from telfairia occidentalis leaves and stems, this work aims to provide an easy and environmentally friendly method to synthesize silver nanoparticles (AgNPs). Furthermore, the research will examine the extract’s natural products chemistry and evaluate its possible anti-inflammatory, anti-diabetic, antioxidant, and antiglycation effects. The silver nanoparticles were characterized through ultraviolet-visible spectroscopy, Fourier transform infrared, and scanning electron microscopy (SEM). The antioxidant, anti-diabetic, and anti-inflammatory activities were conducted using various methods under standard conditions. The visual color change observed indicated the presence of synthesized AgNPs. The creation of silver nanoparticles was verified by surface plasmon resonance scan, which revealed that the nanoparticles had absorption peak at 400 nanometers. Additionally, SEM results provided insights into the size distribution of the AgNPs, ranging from 22 nm-68 nm, 43.66 nm mean. The study suggests that the extract from telfairia occidentalis leaf and stem has the potential to produce AgNPs with antioxidant, anti-inflammatory, anti-diabetic and anti-glycation uses. AgNPs may be valuable in the development of drugs for diabetes treatment and management.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

EUR J SUSTAIN DEV RES, Volume 9, Issue 2, 2025, Article No: em0280

https://doi.org/10.29333/ejosdr/15942

Publication date: 07 Feb 2025

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Article Downloads: 105

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